Centenarian Longevity & Metformin | Nir Barzilai
Live Longer World Podcast #8
Live Longer World Podcast Episode #8 has been released!
My guest in today’s episode is Dr. Nir Barziali. Dr. Nir Barzilai is well-known in the field of longevity and beyond and is the director and chair of several institutes focused on Aging research. Just to name a few, he is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging.
Dr. Barzilai’s research interests are in the biology and genetics of aging, so he has done extensive work studying centenarians and supercentenarians some of which he discusses in today’s episode and also in his book Age Later.
He is currently leading an international effort to approve drugs that can target aging. Targeting Aging with METformin (TAME) is a specific study designed to prove the concept that multi-morbidities of aging can be delayed by metformin, working with the FDA to approve this approach which will serve as a template for future efforts to delay aging and its diseases in humans.
We discuss: 🎙️
Centenarian Longevity genes
What makes centenarians live so long
The role of growth hormones in longevity
Metformin's healthspan benefits for longevity
Metformin & COVID-19
Does Metformin blunt muscle mass?
Does Metformin cause hypoglycemia?
You will find more detailed timestamps below or in the YouTube version of the podcast.
LiveLongerWorld is advocating for longevity science & improved healthspan! To receive new posts and support my work, consider becoming a free or paid subscriber.
Want to receive extensive notes on Dr. Barzilai’s research + future podcast episodes?
I will be releasing more extensive show notes from today’s episode and notes on Dr. Barzilai’s research to premium subscribers, so if you wish to receive them, you can sign up for a premium subscription! Going forward, I plan on releasing extensive research notes on my podcast episodes to my premium subscribers.
Listen to the Podcast:
All Platforms: here
0:00 Live Longer World Intro, Receive Show Notes + Release Updates
2:15 Dr. Nir Barzilai Intro
3:33 Nir's interest in studying centenarians
5:38 Centenarian Longevity Genes; Growth Hormone
10:24 Sex differences in longevity effects of growth hormone IGF-1
13:40 Cholesterol & CETP genes in Centenarians
16:00 How can we apply the findings from centenarian research?
19:50 How did metformin go from being a diabetes drug to longevity drug?
24:50 Targeting hallmarks of aging with metformin
27:27 TAME Trial & working with FDA
31:15 TAME trial as template for developing drugs for aging
31:58 Race-specific differences with Metformin; Could metformin increase risk for Alzheimer's for some?
34:41 Other studies being done on Metformin; No negative effects of Metformin
36:30 Metformin & COVID
37:11 Metformin & Immune System Robustness
38:12 Does Metformin blunt Muscle Mass?
44:45 Metformin Dosage
46:16 Does Metformin cause Hypoglycemia?
49:40 Singapore & Longevity
52:40 SGLT-2 inhibitors for longevity
57:02 What else should we be doing in the longevity field?
58:45 Metformin or Rapamycin?
1:01:00 Support Live Longer World, Social Media, Premium Subscriber Benefits
2021 Live Longer World Podcast Episodes:
It’s a compilation of some of the best & most informative parts of each of my previous 2021 episodes highlighted into this finale episode.
Finally, if you want a recap of all my 2021 podcast episodes, find them here.
Be Notified of Future Podcast Releases!
Hope you enjoy the episode,