Morgan Levine | Epigenetic Clocks, SystemsAge Clock, Epigenetic Reprogramming
Live Longer World Podcast #6
Live Longer World Podcast Episode #6 has been released!
My guest in this episode is Dr. Morgan Levine. She is an Assistant Professor of Pathology and Epidemiology at the Yale School of Medicine.
Morgan runs the lab for Aging in Living Systems at Yale. Her labs works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer’s disease.
I can’t even begin to tell you how much I learned in today’s conversation!
We discuss: 🎙️
Morgan’s work on developing a new Epigenetic clock called the SystemsAge clock, which is very cool and can test the biological age of different organs & systems in your body
Different features of these clocks
Interventions tested using epigenetic clocks
What we know so far on reversing your biological age
Some of the limitations of the clocks
Why she is so excited about Epigenetic Reprogramming
Some of her work around Alzheimer’s disease
Most people are interested in knowing their biological age and Epigenetic Clocks are a way to test it. So I’m sure you will find this conversation on Epigenetic Clocks fascinating and walk away understanding them much better!
I hope you enjoy my conversation with Dr. Morgan Levine!
You will find the timestamps below or in the YouTube version of the podcast.
Listen to the Podcast:
Spotify:
YouTube:
Apple Podcasts:
Podcast Website + Other Platforms: here
Time Stamps: 🤓
0:00 Welcome to Live Longer World
0:37 Dr. Morgan Levine Introduction
2:07 Chronological vs. Biological Age
4:44 Morgan’s interest in Epigenetic Clocks
6:32 DNA Methylation - Epigenetic Modifications with Age
10:00 Why are there changes in DNA Methylation with age?
11:35 SystemsAge Clock - New Epigenetic Clock in Morgan’s lab
16:27 Do certain systems in the body age faster than others?
18:53 How reliable are Epigenetic Clocks? (Traditional clocks are highly unreliable!)
21:31 Does timing of day of biological age test matter?
22:29 Does type of sample (blood vs. saliva) matter for biological age testing?
24:10 Measuring epigenetic age in the brain using SystemsAge Clock
26:46 Does epigenetic age correlate with health biomarkers? Hispanic Mortality Paradox
29:10 SystemAge Clock and COVID-19
32:31 Testing your epigenetic age when you’re sick
34:14 Do temporary interventions like exercise affect baseline biological age levels?
35:22 Error in study that showed 8 week intervention of exercise reduced epigenetic age by 3.23 years
37:48 Testing interventions like Rapamycin with the SystemsAge Clock
39:29 Epigenetic Reprogramming and Yamanaka factors
46:00 Future of Epigenetic Clocks + Parabiosis
49:21 Challenges with Epigenetic Clocks
52:57 Should people trust the consumer biological age tests?
55:26 Elysium Health Index Test
57:13 Morgan’s upcoming book “True Age”
59:22 Do certain aging interventions have more of an impact on Epigenetic Age
1:03:09 Will we converge on one Epigenetic Clock?
1:05:20 What makes those with APOE4 not get Alzheimer’s disease?
1:08:31 Are the epigenetic clocks picking up cellular senescence?
1:11:53 How much of biological age is heritable?
1:14:15 Be notified of upcoming podcasts, support + follow Live Longer World
In Case you missed my previous Episodes:
Episode #5: Aging Interventions - Rapamycin, Caloric Restriction, Sirtuins, NAD+ and the Dog Aging Project with Matt Kaeberlein
Episode #4: Investing in Longevity, Regenerative Medicine, and Longevity Escape Velocity with Dave Gobel, the CEO of Methuselah Foundation
Episode #3: Skin Aging, Senolytics & Building a Longevity Company with Carolina Oliveira, the founder & CEO of OneSkin Technologies
Episode #2: Brain Aging, Tissue Cell Replacement, and Radical Strategy to Fight Aging with Dr. Jean Hebert, Professor of Neuroscience at Albert Einstein College of Medicine
Episode #1: How to Fight Aging, NAD+ Boosters, Senolytics & Curing Atherosclerosis with Reason, the Founder & CEO of Repair Biotechnologies
If you are learning from my work and finding it valuable, I’d love your support in sharing it with your friends & family!
