Best of 2021 Live Longer World Podcast
Longevity Science straight from scientists, entrepreneurs & investors! Live Longer World Podcast #7
2021 Finale Live Longer World Podcast Episode #7 has been released!
Hi everyone! I hope you’re excited for the holiday season and get to spend some quality time with your loved ones :)
I have a special 2021 finale episode of the Live Longer World podcast for you. I've compiled some of the best & most informative parts of each of my previous episodes and highlighted them in this finale episode.
Think of it as a tour showcasing some of the work being done in the field of longevity. Some topics included in the clips are Inflammaging, SystemsAge Clock, Reprogramming, Atherosclerosis, Brain Aging and more.
And if a particular topic or clip captures your attention, you can of course go and watch the entire podcast episode. Hope you enjoy the episode and wishing everyone a happy & healthy holiday season!
Listen to the Best of 2021 Live Longer World Podcast Episode:
Apple Podcasts: here
All Other Platforms: here
Find the previous podcast episodes on all platforms here.
Timestamps for Best of 2021 Live Longer World Episode:
0:00 2021 Recap of 2021 Live Longer World Podcast & Introduction
6:43 Matt Kaeberlein on functional measure of aging
10:40 Morgan Levine on her new SystemsAge Clock
13:55 Reason on senescent cells & senolytics
17:20 Matt Kaeberlein on Inflammaging & immune system
21:52 Carolina Oliveira on Skin Aging & Senescent cells
24:39 Nir Barzilai on Metformin history & benefits
26:52 Morgan Levine on Epigenetic Reprogramming
35:36 Jean Hebert on Tissue Replacement in the Brain
38:10 Matt Kaeberlein on mTOR and Rapamycin as gold standard of longevity research
42:52 Reason on Cholesterol, Atherosclerosis, how to fight it, Repair Biotechnologies
48:27 Morgan Levine on the future of Epigenetic Clocks
51:16 Matt Kaeberlein on “What is Good Science?”
53:11 Nir Barzilai: "Aging can be modified"
Recap of the 2021 Live Longer World Podcast Episodes:
Repair Biotechnologies is a company working to fight atherosclerosis. Reason also writes the popular blog FightAging.org where he distills important longevity research. In my conversation with him, we discussed how to think of aging simply, the differences between slowing and reversing aging, NAD+ boosters and their effectiveness, reversing aging using senolytics, how his company is working on a gene therapy to reverse artherosclerosis and cardiovascular disease, problems with Alzheimer's research, working towards aging rejuvenation therapies, how one can get involved in the aging space, and much more.
Dr. Jean Hebert’s lab is developing ways to use cell and tissue replacements to repair and rejuvenate the brain. More specifically, the Hébert Lab is engineering tissue that increasingly resembles normal neocortex, the part of our brain that performs our highest cognitive functions, and testing the ability of this tissue to integrate with the host brain. We had an extremely interesting conversation ranging from why Dr. Hebert thinks the other methods to fight aging may not work if the goal is to beat aging, we discuss 3D organs and tissue cell replacement and we also discuss the neocortex and what it takes to replace one and lastly we talk about how plasticity in the brain works.
OneSkin is pioneering technologies aimed at extending human healthspan. Their first product is a topical supplement designed to extend your skinspan by improving skin health and skin strength. Their proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative implications of aging. We discussed Skin Health for Overall Longevity, Skin Overlooked in Longevity Research, Cellular Senescence, OneSkin vs. Senolytics, Improving HealthSpan & more!
Episode webpage: here
Methuselah Foundation has donated several million dollars for the advancement of longevity research and regenerative medicine. Their goal is to make make 90 the New 50 by 2030. Dave was an entrepreneur before he decided to jump into the field of longevity. In my conversation with him, we discuss how he got excited about longevity research, companies funded by Methuselah including Oisin Biotechnologies, the concept of longevity escape velocity, his work with the super centenarian research foundation, how one can get involved in funding longevity companies and more.
Episode webpage: here
Dr. Matt Kaeberlein has been around the field of aging for a long time and knows more about the work in the aging field than perhaps anyone else. This was a comprehensive conversation where we spoke about how Matt thinks of aging from a functional perspective, caloric restriction and aging, whether NAD+ precursors are effective in slowing aging, the role of sirtuins. We discuss quite a bit on rapamycin and how it’s shown to be effective in improving the health of mice. Matt is very excited about the potential benefits of Rapamycin in reversing aging and he got me excited too. Matt is also working on the Dog Aging project and in trying to understand aging in dogs. Finally, we end the conversation by talking a bit on what good scientific practices should look like. Matt approaches his work with an unbiased lens and that’s very respectable.
Episode webpage: here
Dr. Morgan Levine runs the lab for Aging in Living Systems at Yale. Her lab works on Epigenetic Clocks, Epigenetic reprogramming, cellular aging trajectories, and in trying to understand the causes of Alzheimer’s disease. We extensively discussed Morgan’s work on developing a new Epigenetic clock called the SystemsAge clock, which is very cool and can test the biological age of different organs & systems in your body. We also spoke of different features of these clocks, interventions tested, what we know so far on reversing your biological age, some of the limitations of the clocks, why she is so excited about epigenetic reprogramming, and some of her work around Alzheimer’s disease. Most people are interested in knowing their biological age and epigenetic clocks are a way to test it. So I’m sure you will find this conversation on epigenetic clocks fascinating and walk away understanding them much better!
Episode webpage: here
That’s a Wrap on 2021 Live Longer World Podcast!
I started this podcast a few months ago to keep following my curiosity, to learn more on longevity science and to share the information with others who wish to know how to improve their lifespan and healthspan! I’ve had a blast recording and releasing the 7 episodes so far and I can’t wait to share more longevity science podcasts with you in 2022!
If you are out of ideas for gifts this holiday season, you can give your loved ones the gift of longevity and share this newsletter and podcast with them! :)
During the holidays, rest well and feast up because we’ll return to fasting and boosting autophagy (removing damaged components of our cells) in the new year! :P
Jokes apart, wishing everyone a Merry Christmas and a Happy New Year! See you in 2022 ready to be healthy and boost longevity!